U is a potent phospholipase C inhibitor or PIPLC inhibitor U is widely used as a tool to investigate the involvement of the phosphoinositidespecific phospholipase C (PLC) in signal transduction, particularly in studies attempting to characterize pathways leading to intracellular Ca2 mobilization upon agonist challenge U directly blocks PLC isoenzymes in vivo andU also inhibited PMN adherence to and transmigration through TNFalphaactivated endothelium (IC50 < 50 nM) Further, U suppressed interleukin8, Nformylmethionylleucylphenylalanine and PMAstimulated upregulation of the beta 2integrin, Mac1 (CD11b/CD18), on the PMN surface (IC50 < 13 microM)U is an inhibitor of phospholipase C, phospholipase , and 5LO(5lipoxygenase) Biological Activity Description U is an unselective PLC inhibitor U has been utilized extensively to probe PLC signalling in cells of the immune system, in neurons and in cardiomyocytes, among many other cell types
U 99 Hplc Plc Inhibitor Adooq
U-73122 hydrate